PINK1 Deficiency Ameliorates Cisplatin-Induced Acute Kidney Injury in Rats
Identifieur interne : 000558 ( Main/Exploration ); précédent : 000557; suivant : 000559PINK1 Deficiency Ameliorates Cisplatin-Induced Acute Kidney Injury in Rats
Auteurs : Li Zhou [République populaire de Chine] ; Ling Zhang [République populaire de Chine] ; Yu Zhang [République populaire de Chine] ; Xuan Yu [République populaire de Chine] ; Xiuping Sun [République populaire de Chine] ; Tao Zhu [République populaire de Chine] ; Xianglei Li [République populaire de Chine] ; Wei Liang [République populaire de Chine] ; Yunlin Han [République populaire de Chine] ; Chuan Qin [République populaire de Chine]Source :
- Frontiers in Physiology [ 1664-042X ] ; 2019.
Abstract
Mitophagy plays a key role in cleaning damaged and depolarized mitochondria to maintain cellular homeostasis and viability. Although it was originally found in neurodegenerative diseases, mitophagy is reported to play an important role in acute kidney injury. PINK1 and Parkin are key molecules in mitophagy pathway. Here, we used PINK1 knockout rats to examine the role of PINK1/Parkin-mediated mitophagy in cisplatin nephrotoxicity. After cisplatin treatment, PINK1 knockout rats showed lower plasma creatinine and less tubular damage when compared with wild-type rats. Meanwhile, mitophagy indicated by autophagosome formation and LC3B-II accumulation was also attenuated in PINK1 knockout rats. Renal expression of PINK1 and Parkin were down-regulated while BNIP3L was up-regulated by cisplatin treatment, indicating a major role of BNIP3/BNIP3L pathway in cisplatin-induced mitophagy. Transmission electron microscopy showed that PINK1 deficiency inhibited cisplatin-induced mitochondrial fragmentation indicating an involvement of mitochondrial fusion and fission. Renal expression of mitochondrial dynamics related proteins including
Url:
DOI: 10.3389/fphys.2019.01225
PubMed: 31607953
PubMed Central: 6773839
Affiliations:
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Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Yunlin" sort="Han, Yunlin" uniqKey="Han Y" first="Yunlin" last="Han">Yunlin Han</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de 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Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Ling" sort="Zhang, Ling" uniqKey="Zhang L" first="Ling" last="Zhang">Ling Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Xuan" sort="Yu, Xuan" uniqKey="Yu X" first="Xuan" last="Yu">Xuan Yu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Xiuping" sort="Sun, Xiuping" uniqKey="Sun X" first="Xiuping" last="Sun">Xiuping Sun</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Tao" sort="Zhu, Tao" uniqKey="Zhu T" first="Tao" last="Zhu">Tao Zhu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Xianglei" sort="Li, Xianglei" uniqKey="Li X" first="Xianglei" last="Li">Xianglei Li</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Wei" sort="Liang, Wei" uniqKey="Liang W" first="Wei" last="Liang">Wei Liang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Yunlin" sort="Han, Yunlin" uniqKey="Han Y" first="Yunlin" last="Han">Yunlin Han</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Peking Union Medicine College (PUMC)</institution>,<addr-line>Beijing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Physiology</title><idno type="eISSN">1664-042X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mitophagy plays a key role in cleaning damaged and depolarized mitochondria to maintain cellular homeostasis and viability. Although it was originally found in neurodegenerative diseases, mitophagy is reported to play an important role in acute kidney injury. PINK1 and Parkin are key molecules in mitophagy pathway. Here, we used PINK1 knockout rats to examine the role of PINK1/Parkin-mediated mitophagy in cisplatin nephrotoxicity. After cisplatin treatment, PINK1 knockout rats showed lower plasma creatinine and less tubular damage when compared with wild-type rats. Meanwhile, mitophagy indicated by autophagosome formation and LC3B-II accumulation was also attenuated in PINK1 knockout rats. Renal expression of PINK1 and Parkin were down-regulated while BNIP3L was up-regulated by cisplatin treatment, indicating a major role of BNIP3/BNIP3L pathway in cisplatin-induced mitophagy. Transmission electron microscopy showed that PINK1 deficiency inhibited cisplatin-induced mitochondrial fragmentation indicating an involvement of mitochondrial fusion and fission. Renal expression of mitochondrial dynamics related proteins including <italic>Fis1</italic>, <italic>Drp1</italic>, <italic>Mfn1</italic>, <italic>Mfn2</italic>, and <italic>Opa1</italic> were checked by real-time PCR and western blots. The results showed PINK1 deficiency distinctly prevented cisplatin-induced up-regulation of DRP1. Finally, PINK1 deficiency alleviated cisplatin-induced tubular apoptosis indicated by TUNEL assay as well as the expression of caspase3 and cleaved caspase3. Together, these results suggested PINK1 deficiency ameliorated cisplatin-induced acute kidney injury in rats, possibly via inhibiting DRP1-mediated mitochondrial fission and excessive mitophagy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alves Da Costa, C" uniqKey="Alves Da Costa C">C. Alves da Costa</name></author><author><name sortKey="Duplan, E" uniqKey="Duplan E">E. Duplan</name></author><author><name sortKey="Rouland, L" uniqKey="Rouland L">L. Rouland</name></author><author><name sortKey="Checler, F" uniqKey="Checler F">F. Checler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brooks, C" uniqKey="Brooks C">C. Brooks</name></author><author><name sortKey="Wei, Q" uniqKey="Wei Q">Q. Wei</name></author><author><name sortKey="Cho, S G" uniqKey="Cho S">S. G. Cho</name></author><author><name sortKey="Dong, Z" uniqKey="Dong Z">Z. Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buhlman, L" uniqKey="Buhlman L">L. Buhlman</name></author><author><name sortKey="Damiano, M" uniqKey="Damiano M">M. Damiano</name></author><author><name sortKey="Bertolin, G" uniqKey="Bertolin G">G. Bertolin</name></author><author><name sortKey="Ferrando Miguel, R" uniqKey="Ferrando Miguel R">R. Ferrando-Miguel</name></author><author><name sortKey="Lombes, A" uniqKey="Lombes A">A. Lombes</name></author><author><name sortKey="Brice, A" uniqKey="Brice A">A. Brice</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che, R" uniqKey="Che R">R. Che</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y. Yuan</name></author><author><name sortKey="Huang, S" uniqKey="Huang S">S. Huang</name></author><author><name sortKey="Zhang, A" uniqKey="Zhang A">A. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chien, C T" uniqKey="Chien C">C. T. Chien</name></author><author><name sortKey="Shyue, S K" uniqKey="Shyue S">S. K. Shyue</name></author><author><name sortKey="Lai, M K" uniqKey="Lai M">M. K. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dagda, R K" uniqKey="Dagda R">R. K. Dagda</name></author><author><name sortKey="Cherra, S J" uniqKey="Cherra S">S. J. Cherra</name></author><author><name sortKey="Kulich, S M" uniqKey="Kulich S">S. M. Kulich</name></author><author><name sortKey="Tandon, A" uniqKey="Tandon A">A. Tandon</name></author><author><name sortKey="Park, D" uniqKey="Park D">D. Park</name></author><author><name sortKey="Chu, C T" uniqKey="Chu C">C. T. Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dave, K D" uniqKey="Dave K">K. D. Dave</name></author><author><name sortKey="De Silva, S" uniqKey="De Silva S">S. De Silva</name></author><author><name sortKey="Sheth, N P" uniqKey="Sheth N">N. P. Sheth</name></author><author><name sortKey="Ramboz, S" uniqKey="Ramboz S">S. Ramboz</name></author><author><name sortKey="Beck, M J" uniqKey="Beck M">M. J. Beck</name></author><author><name sortKey="Quang, C" uniqKey="Quang C">C. Quang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decuypere, J P" uniqKey="Decuypere J">J. P. Decuypere</name></author><author><name sortKey="Ceulemans, L J" uniqKey="Ceulemans L">L. J. Ceulemans</name></author><author><name sortKey="Agostinis, P" uniqKey="Agostinis P">P. Agostinis</name></author><author><name sortKey="Monbaliu, D" uniqKey="Monbaliu D">D. Monbaliu</name></author><author><name sortKey="Naesens, M" uniqKey="Naesens M">M. Naesens</name></author><author><name sortKey="Pirenne, J" uniqKey="Pirenne J">J. Pirenne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dilruba, S" uniqKey="Dilruba S">S. Dilruba</name></author><author><name sortKey="Kalayda, G V" uniqKey="Kalayda G">G. V. Kalayda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eiyama, A" uniqKey="Eiyama A">A. Eiyama</name></author><author><name sortKey="Okamoto, K" uniqKey="Okamoto K">K. Okamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Filfan, M" uniqKey="Filfan M">M. Filfan</name></author><author><name sortKey="Sandu, R E" uniqKey="Sandu R">R. E. Sandu</name></author><author><name sortKey="Zavaleanu, A D" uniqKey="Zavaleanu A">A. D. Zavaleanu</name></author><author><name sortKey="Gresita, A" uniqKey="Gresita A">A. GresiTa</name></author><author><name sortKey="Glavan, D G" uniqKey="Glavan D">D. G. Glavan</name></author><author><name sortKey="Olaru, D G" uniqKey="Olaru D">D. G. Olaru</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleck, C" uniqKey="Fleck C">C. Fleck</name></author><author><name sortKey="Heller, J" uniqKey="Heller J">J. Heller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frank, S" uniqKey="Frank S">S. Frank</name></author><author><name sortKey="Gaume, B" uniqKey="Gaume B">B. Gaume</name></author><author><name sortKey="Bergmann Leitner, E S" uniqKey="Bergmann Leitner E">E. S. Bergmann-Leitner</name></author><author><name sortKey="Leitner, W W" uniqKey="Leitner W">W. W. Leitner</name></author><author><name sortKey="Robert, E G" uniqKey="Robert E">E. G. Robert</name></author><author><name sortKey="Catez, F" uniqKey="Catez F">F. Catez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goulding, N E" uniqKey="Goulding N">N. E. Goulding</name></author><author><name sortKey="Johns, E J" uniqKey="Johns E">E. J. Johns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, Y Y" uniqKey="Gu Y">Y. Y. Gu</name></author><author><name sortKey="Huang, P" uniqKey="Huang P">P. Huang</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author><author><name sortKey="Liu, Y Y" uniqKey="Liu Y">Y. Y. Liu</name></author><author><name sortKey="Liu, G" uniqKey="Liu G">G. Liu</name></author><author><name sortKey="Wang, Y H" uniqKey="Wang Y">Y. H. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, A M" uniqKey="Hall A">A. M. Hall</name></author><author><name sortKey="Rhodes, G J" uniqKey="Rhodes G">G. J. Rhodes</name></author><author><name sortKey="Sandoval, R M" uniqKey="Sandoval R">R. M. Sandoval</name></author><author><name sortKey="Corridon, P R" uniqKey="Corridon P">P. R. Corridon</name></author><author><name sortKey="Molitoris, B A" uniqKey="Molitoris B">B. A. Molitoris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartleben, B" uniqKey="Hartleben B">B. Hartleben</name></author><author><name sortKey="Godel, M" uniqKey="Godel M">M. Godel</name></author><author><name sortKey="Meyer Schwesinger, C" uniqKey="Meyer Schwesinger C">C. Meyer-Schwesinger</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author><author><name sortKey="Ulrich, T" uniqKey="Ulrich T">T. Ulrich</name></author><author><name sortKey="Kobler, S" uniqKey="Kobler S">S. Kobler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Kelly, D J" uniqKey="Kelly D">D. J. Kelly</name></author><author><name sortKey="Tan, C Y" uniqKey="Tan C">C. Y. Tan</name></author><author><name sortKey="Gill, A" uniqKey="Gill A">A. Gill</name></author><author><name sortKey="Cheng, D" uniqKey="Cheng D">D. Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ichinomiya, M" uniqKey="Ichinomiya M">M. Ichinomiya</name></author><author><name sortKey="Shimada, A" uniqKey="Shimada A">A. Shimada</name></author><author><name sortKey="Ohta, N" uniqKey="Ohta N">N. Ohta</name></author><author><name sortKey="Inouchi, E" uniqKey="Inouchi E">E. Inouchi</name></author><author><name sortKey="Ogihara, K" uniqKey="Ogihara K">K. Ogihara</name></author><author><name sortKey="Naya, Y" uniqKey="Naya Y">Y. Naya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishihara, M" uniqKey="Ishihara M">M. Ishihara</name></author><author><name sortKey="Urushido, M" uniqKey="Urushido M">M. Urushido</name></author><author><name sortKey="Hamada, K" uniqKey="Hamada K">K. Hamada</name></author><author><name sortKey="Matsumoto, T" uniqKey="Matsumoto T">T. Matsumoto</name></author><author><name sortKey="Shimamura, Y" uniqKey="Shimamura Y">Y. Shimamura</name></author><author><name sortKey="Ogata, K" uniqKey="Ogata K">K. Ogata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishimoto, Y" uniqKey="Ishimoto Y">Y. Ishimoto</name></author><author><name sortKey="Inagi, R" uniqKey="Inagi R">R. Inagi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, Z" uniqKey="Jia Z">Z. Jia</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Aoyagi, T" uniqKey="Aoyagi T">T. Aoyagi</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author><author><name sortKey="Yang, T" uniqKey="Yang T">T. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, M" uniqKey="Jiang M">M. Jiang</name></author><author><name sortKey="Liu, K" uniqKey="Liu K">K. Liu</name></author><author><name sortKey="Luo, J" uniqKey="Luo J">J. Luo</name></author><author><name sortKey="Dong, Z" uniqKey="Dong Z">Z. Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, M" uniqKey="Jiang M">M. Jiang</name></author><author><name sortKey="Wei, Q" uniqKey="Wei Q">Q. Wei</name></author><author><name sortKey="Dong, G" uniqKey="Dong G">G. Dong</name></author><author><name sortKey="Komatsu, M" uniqKey="Komatsu M">M. Komatsu</name></author><author><name sortKey="Su, Y" uniqKey="Su Y">Y. Su</name></author><author><name sortKey="Dong, Z" uniqKey="Dong Z">Z. Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaushal, G P" uniqKey="Kaushal G">G. P. Kaushal</name></author><author><name sortKey="Shah, S V" uniqKey="Shah S">S. V. Shah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kimura, T" uniqKey="Kimura T">T. Kimura</name></author><author><name sortKey="Takabatake, Y" uniqKey="Takabatake Y">Y. Takabatake</name></author><author><name sortKey="Takahashi, A" uniqKey="Takahashi A">A. Takahashi</name></author><author><name sortKey="Kaimori, J Y" uniqKey="Kaimori J">J. Y. Kaimori</name></author><author><name sortKey="Matsui, I" uniqKey="Matsui I">I. Matsui</name></author><author><name sortKey="Namba, T" uniqKey="Namba T">T. Namba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kubli, D A" uniqKey="Kubli D">D. A. Kubli</name></author><author><name sortKey="Gustafsson, A B" uniqKey="Gustafsson A">A. B. Gustafsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, N" uniqKey="Li N">N. Li</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Jiang, C" uniqKey="Jiang C">C. Jiang</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Du, M" uniqKey="Du M">M. Du</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="Ma, X" uniqKey="Ma X">X. Ma</name></author><author><name sortKey="Wu, L" uniqKey="Wu L">L. Wu</name></author><author><name sortKey="Guo, F" uniqKey="Guo F">F. Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Q" uniqKey="Lin Q">Q. Lin</name></author><author><name sortKey="Li, S" uniqKey="Li S">S. Li</name></author><author><name sortKey="Jiang, N" uniqKey="Jiang N">N. Jiang</name></author><author><name sortKey="Shao, X" uniqKey="Shao X">X. Shao</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M. Zhang</name></author><author><name sortKey="Jin, H" uniqKey="Jin H">H. Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author><author><name sortKey="Hartleben, B" uniqKey="Hartleben B">B. Hartleben</name></author><author><name sortKey="Kretz, O" uniqKey="Kretz O">O. Kretz</name></author><author><name sortKey="Wiech, T" uniqKey="Wiech T">T. Wiech</name></author><author><name sortKey="Igarashi, P" uniqKey="Igarashi P">P. Igarashi</name></author><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N. Mizushima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author><author><name sortKey="Jia, Z" uniqKey="Jia Z">Z. Jia</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Ling, H" uniqKey="Ling H">H. Ling</name></author><author><name sortKey="Zhou, S F" uniqKey="Zhou S">S. F. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lutz, A K" uniqKey="Lutz A">A. K. Lutz</name></author><author><name sortKey="Exner, N" uniqKey="Exner N">N. Exner</name></author><author><name sortKey="Fett, M E" uniqKey="Fett M">M. E. Fett</name></author><author><name sortKey="Schlehe, J S" uniqKey="Schlehe J">J. S. Schlehe</name></author><author><name sortKey="Kloos, K" uniqKey="Kloos K">K. Kloos</name></author><author><name sortKey="Lammermann, K" uniqKey="Lammermann K">K. Lammermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manohar, S" uniqKey="Manohar S">S. Manohar</name></author><author><name sortKey="Leung, N" uniqKey="Leung N">N. Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcwilliams, T G" uniqKey="Mcwilliams T">T. G. McWilliams</name></author><author><name sortKey="Muqit, M M" uniqKey="Muqit M">M. M. Muqit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, J N" uniqKey="Meyer J">J. N. Meyer</name></author><author><name sortKey="Leuthner, T C" uniqKey="Leuthner T">T. C. Leuthner</name></author><author><name sortKey="Luz, A L" uniqKey="Luz A">A. L. Luz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, R P" uniqKey="Miller R">R. P. Miller</name></author><author><name sortKey="Tadagavadi, R K" uniqKey="Tadagavadi R">R. K. Tadagavadi</name></author><author><name sortKey="Ramesh, G" uniqKey="Ramesh G">G. Ramesh</name></author><author><name sortKey="Reeves, W B" uniqKey="Reeves W">W. B. Reeves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ney, P A" uniqKey="Ney P">P. A. Ney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pallet, N" uniqKey="Pallet N">N. Pallet</name></author><author><name sortKey="Bouvier, N" uniqKey="Bouvier N">N. Bouvier</name></author><author><name sortKey="Legendre, C" uniqKey="Legendre C">C. Legendre</name></author><author><name sortKey="Gilleron, J" uniqKey="Gilleron J">J. Gilleron</name></author><author><name sortKey="Codogno, P" uniqKey="Codogno P">P. Codogno</name></author><author><name sortKey="Beaune, P" uniqKey="Beaune P">P. Beaune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parone, P A" uniqKey="Parone P">P. A. Parone</name></author><author><name sortKey="James, D I" uniqKey="James D">D. I. James</name></author><author><name sortKey="Da Cruz, S" uniqKey="Da Cruz S">S. Da Cruz</name></author><author><name sortKey="Mattenberger, Y" uniqKey="Mattenberger Y">Y. Mattenberger</name></author><author><name sortKey="Donze, O" uniqKey="Donze O">O. Donze</name></author><author><name sortKey="Barja, F" uniqKey="Barja F">F. Barja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peres, L A" uniqKey="Peres L">L. A. Peres</name></author><author><name sortKey="Da Cunha, A D" uniqKey="Da Cunha A">A. D. da Cunha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shintani, T" uniqKey="Shintani T">T. Shintani</name></author><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D. J. Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sugioka, R" uniqKey="Sugioka R">R. Sugioka</name></author><author><name sortKey="Shimizu, S" uniqKey="Shimizu S">S. Shimizu</name></author><author><name sortKey="Tsujimoto, Y" uniqKey="Tsujimoto Y">Y. Tsujimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, C" uniqKey="Tang C">C. Tang</name></author><author><name sortKey="Han, H" uniqKey="Han H">H. Han</name></author><author><name sortKey="Yan, M" uniqKey="Yan M">M. Yan</name></author><author><name sortKey="Zhu, S" uniqKey="Zhu S">S. Zhu</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voigt, A" uniqKey="Voigt A">A. Voigt</name></author><author><name sortKey="Berlemann, L A" uniqKey="Berlemann L">L. A. Berlemann</name></author><author><name sortKey="Winklhofer, K F" uniqKey="Winklhofer K">K. F. Winklhofer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B. Liu</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Pang, Q" uniqKey="Pang Q">Q. Pang</name></author><author><name sortKey="Agrawal, S G" uniqKey="Agrawal S">S. G. Agrawal</name></author><author><name sortKey="Jia, L" uniqKey="Jia L">L. Jia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Tang, C" uniqKey="Tang C">C. Tang</name></author><author><name sortKey="Cai, J" uniqKey="Cai J">J. Cai</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G. Chen</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, H H" uniqKey="Wu H">H. H. Wu</name></author><author><name sortKey="Hsiao, T Y" uniqKey="Hsiao T">T. Y. Hsiao</name></author><author><name sortKey="Chien, C T" uniqKey="Chien C">C. T. Chien</name></author><author><name sortKey="Lai, M K" uniqKey="Lai M">M. K. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, L" uniqKey="Xiao L">L. Xiao</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y. Xu</name></author><author><name sortKey="Tang, D" uniqKey="Tang D">D. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Ni, H M" uniqKey="Ni H">H. M. Ni</name></author><author><name sortKey="Xiong, A" uniqKey="Xiong A">A. Xiong</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name></author><author><name sortKey="Sesaki, H" uniqKey="Sesaki H">H. Sesaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author><author><name sortKey="Liu, F" uniqKey="Liu F">F. Liu</name></author><author><name sortKey="Dong, Z" uniqKey="Dong Z">Z. Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeh, C H" uniqKey="Yeh C">C. H. Yeh</name></author><author><name sortKey="Hsu, S P" uniqKey="Hsu S">S. P. Hsu</name></author><author><name sortKey="Yang, C C" uniqKey="Yang C">C. C. Yang</name></author><author><name sortKey="Chien, C T" uniqKey="Chien C">C. T. Chien</name></author><author><name sortKey="Wang, N P" uniqKey="Wang N">N. P. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name></author><author><name sortKey="Wu, S" uniqKey="Wu S">S. Wu</name></author><author><name sortKey="Xing, D" uniqKey="Xing D">D. Xing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, C" uniqKey="Zhao C">C. Zhao</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J. Qi</name></author><author><name sortKey="Duan, S" uniqKey="Duan S">S. Duan</name></author><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z. Huang</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, C" uniqKey="Zhao C">C. Zhao</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name></author><author><name sortKey="An, X" uniqKey="An X">X. An</name></author><author><name sortKey="Duan, S" uniqKey="Duan S">S. Duan</name></author><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z. Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, J" uniqKey="Zhou J">J. Zhou</name></author><author><name sortKey="Fan, Y" uniqKey="Fan Y">Y. Fan</name></author><author><name sortKey="Zhong, J" uniqKey="Zhong J">J. Zhong</name></author><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z. Huang</name></author><author><name sortKey="Huang, T" uniqKey="Huang T">T. Huang</name></author><author><name sortKey="Lin, S" uniqKey="Lin S">S. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name></author><author><name sortKey="Wei, X H" uniqKey="Wei X">X. H. Wei</name></author><author><name sortKey="Pan, C S" uniqKey="Pan C">C. S. Pan</name></author><author><name sortKey="Yan, L" uniqKey="Yan L">L. Yan</name></author><author><name sortKey="Gu, Y Y" uniqKey="Gu Y">Y. Y. Gu</name></author><author><name sortKey="Sun, K" uniqKey="Sun K">K. Sun</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhou, Li" sort="Zhou, Li" uniqKey="Zhou L" first="Li" last="Zhou">Li Zhou</name></noRegion><name sortKey="Han, Yunlin" sort="Han, Yunlin" uniqKey="Han Y" first="Yunlin" last="Han">Yunlin Han</name><name sortKey="Han, Yunlin" sort="Han, Yunlin" uniqKey="Han Y" first="Yunlin" last="Han">Yunlin Han</name><name sortKey="Li, Xianglei" sort="Li, Xianglei" uniqKey="Li X" first="Xianglei" last="Li">Xianglei Li</name><name sortKey="Li, Xianglei" sort="Li, Xianglei" uniqKey="Li X" first="Xianglei" last="Li">Xianglei Li</name><name sortKey="Liang, Wei" sort="Liang, Wei" uniqKey="Liang W" first="Wei" last="Liang">Wei Liang</name><name sortKey="Liang, Wei" sort="Liang, Wei" uniqKey="Liang W" first="Wei" last="Liang">Wei Liang</name><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><name sortKey="Sun, Xiuping" sort="Sun, Xiuping" uniqKey="Sun X" first="Xiuping" last="Sun">Xiuping Sun</name><name sortKey="Sun, Xiuping" sort="Sun, Xiuping" uniqKey="Sun X" first="Xiuping" last="Sun">Xiuping Sun</name><name sortKey="Yu, Xuan" sort="Yu, Xuan" uniqKey="Yu X" first="Xuan" last="Yu">Xuan Yu</name><name sortKey="Yu, Xuan" sort="Yu, Xuan" uniqKey="Yu X" first="Xuan" last="Yu">Xuan Yu</name><name sortKey="Zhang, Ling" sort="Zhang, Ling" uniqKey="Zhang L" first="Ling" last="Zhang">Ling Zhang</name><name sortKey="Zhang, Ling" sort="Zhang, Ling" uniqKey="Zhang L" first="Ling" last="Zhang">Ling Zhang</name><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><name sortKey="Zhou, Li" sort="Zhou, Li" uniqKey="Zhou L" first="Li" last="Zhou">Li Zhou</name><name sortKey="Zhu, Tao" sort="Zhu, Tao" uniqKey="Zhu T" first="Tao" last="Zhu">Tao Zhu</name><name sortKey="Zhu, Tao" sort="Zhu, Tao" uniqKey="Zhu T" first="Tao" last="Zhu">Tao Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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